Robert Wysocki – polski biolog molekularny, genetyk i mikrobiolog; prof. dr hab. nauk biologicznych, dyrektor i profesor nadzwyczajny Instytutu Biologii Eksperymentalnej, oraz Instytutu Genetyki i Mikrobiologii Wydziału Nauk Biologicznych Uniwersytetu Wrocławskiego.
Życiorys 24 czerwca 1999 obronił pracę doktorską Struktura i funkcja genów ACR3 i ACR2 warunkujących oporność komórek drożdży Saccharomyces cerevisiae na sole arsenu, otrzymując doktorat, a 6 października 2005 habilitował się na podstawie oceny dorobku naukowego i pracy zatytułowanej Mechanizmy tolerancji komórek drożdży Saccharomyces cerevisiae na arsen i antymon. 7 sierpnia 2012 nadano mu tytuł profesora w zakresie nauk biologicznych.
Został zatrudniony na stanowisku dyrektora i profesora nadzwyczajnego w Instytucie Biologii Eksperymentalnej, oraz w Instytucie Genetyki i Mikrobiologii na Wydziale Nauk Biologicznych Uniwersytetu Wrocławskiego.
Wybrane publikacje naukowe Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel. Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p. The yeast permease Acr3p is a dual arsenite and antimonite plasma membrane transporter. The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast. CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage. Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces cerevisiae. Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p. Acr3p is a plasma membrane antiporter that catalyzes As(III)/H(+) and Sb(III)/H(+) exchange in Saccharomyces cerevisiae. Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast Oxidative stress and replication-independent DNA breakage induced by arsenic in Saccharomyces cerevisiae Disentangling genetic and epigenetic determinants of ultrafast adaptation The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle. The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast Arsenic and antimony transporters in eukaryotes Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species. How Saccharomyces cerevisiae copes with toxic metals and metalloids. Different sensitivities of mutants and chimeric forms of human muscle and liver fructose-1,6-bisphosphatases towards AMP. The Swi2-Snf2-like protein Uls1 is involved in replication stress response. New insights into cohesin loading. Transmembrane topology of the arsenite permease Acr3 from Saccharomyces cerevisiae. Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress. The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1. Metalloid tolerance based on phytochelatins is not functionally equivalent to the arsenite transporter Acr3p. The genetic characteristics Saccharomyces cerevisiae aci(+) mutants. Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress. DNA Damage Tolerance Pathway Choice Through Uls1 Modulation of Srs2 SUMOylation in Saccharomyces cerevisiae. Identification of critical residues for transport activity of Acr3p, the Saccharomyces cerevisiae As(III)/H+ antiporter. Arsenical resistance genes in Saccharomyces douglasii and other yeast species undergo rapid evolution involving genomic rearrangements and duplications. Mass-murdering: deletion of twenty-three ORFs from Saccharomyces cerevisiae chromosome XI reveals five genes essential for growth and three genes conferring detectable mutant phenotype Error-free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin Elucidating the response of Kluyveromyces lactis to arsenite and peroxide stress and the role of the transcription factor KlYap8 Mechanisms of toxic metal tolerance in yeast Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression The Emerging Role of Cohesin in the DNA Damage Response The ancillary N-terminal region of the yeast AP-1 transcription factor Yap8 contributes to its DNA binding specificity Coupling of RNA polymerase III assembly to cell cycle progression in Saccharomyces cerevisiae Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors Arsenic and Yeast Aquaglyceroporin Saccharomyces cerevisiae as a Model Organism for Elucidating Arsenic Tolerance Mechanisms
Przypisy
Kategoria:Polscy mikrobiolodzy Kategoria:Nauczyciele akademiccy Wydziału Nauk Biologicznych Uniwersytetu Wrocławskiego Kategoria:Urodzeni w XX wieku